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Journal of Chemistry
Volume 2013, Article ID 926723, 8 pages
Research Article

Synthesis and Biological Evaluation of Novel -Alkylidene Butenolides

1School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou, Henan 450046, China
2School of Pharmaceutical Science, Zhengzhou University, Ke Xue Da Dao 100, Zhengzhou 450001, China

Received 7 May 2013; Revised 10 July 2013; Accepted 14 July 2013

Academic Editor: Augusto C. Tome

Copyright © 2013 Gai-Zhi Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Three new series of 4-substituted-5-alkylidene-2,5-dihydrofuran-2-ones were synthesized. The in vitro activity test results showed that some of them exhibited good antibacterial and cytotoxic activities. Among them compound 5c showed the most potent antibacterial activity against Escherichia coli with the MIC value of 20.00 μg/mL. Compound 9c showed good cytotoxic activity against Ec9706 cells with value of 19.39 μM, better than that of the reference compound fluorouracil ( μM).