Synthesis and Biological Evaluation of Novel 𝜸-Alkylidene Butenolides

Table 1

MIC^a,b of butenolide derivatives against Escherichia coli and Staphylococcus aureus.

Com	EC^c	SA^d	Com	EC^c	SA^d
3	120.13	101.46	7b	82.58	82.58
4	90.83	90.83	7c	Nd^e	Nd
5a	79.30	93.59	7d	Nd	Nd
5b	>200	>200	8	93.59	93.59
5c	20.00	99.10	9a	132.58	132.58
5d	82.58	100.56	9b	93.59	93.59
5e	82.58	82.58	9c	90.83	110.62
5f	93.59	93.59	9d	90.83	90.83
6	Nd^e	Nd	9e	82.58	82.58
7a	82.58	>200	Chloramphenicol	64	110^f

aMIC (µg/mL): minimum inhibitory concentration.
bDefined as 100% inhibition of the growth of control. cEscherichia coli; dStaphylococcus aureus. eNo detection. fMIC90 (µg/mL).