Synthesis and Biological Evaluation of Novel 𝜸-Alkylidene Butenolides

Table 2

^aIC₅₀ values of butenolides against Ec9706 cells, Hela cells, SPCA1 cells and HepG-2 cells.

Com	Ec9706	HepG-2	SPCA1	Hela	Com	Ec9706	HepG-2	SPCA1	Hela
3	89.45	97.38	100.02	92.87	7b	81.34	NI	NI	113
4	78.23	80.16	108	70.36	7c	NI^b	116	NI	84.28
5a	50.69	56.87	NI	NI	7d	104	178	89.19	Nd^c
5b	100	88.64	200	90.16	8	NI^b	102	116	128
5c	76.34	66.58	80.25	56.37	9a	77.59	67.51	102	86.31
5d	NI	NI	NI	Nd	9b	131	59.13	106	156
5e	96.12	132	101	87.69	9c	19.39	49.96	50.15	80.04
5f	55.87	86.92	NI	77.42	9d	Nd	200	Nd	Nd
6	98.39	123	147	NI	9e	151	125	143	74.13
7a	69.36	86.29	73.56	99.13	5-Fu ^d	37.74	18.26	32.50	25.39

aIC₅₀ (µM): the concentration of substance that provides 50% inhibition.
bNo inhibition at 100 μM. cNo detection. ^dFluorouracil.