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Journal of Chemistry
Volume 2013, Article ID 937454, 2 pages
Research Article

Improved Convenient Synthesis of Benzoyl Metronidazole: A Nitroimidazole Antibiotics

Ningxia Engineering Research Center for Hui Medicine Modernization, School of Pharmacy, Ningxia Medical University, Yinchuan, Ningxia 750004, China

Received 22 June 2012; Revised 7 August 2012; Accepted 23 August 2012

Academic Editor: Casimiro Mantell

Copyright © 2013 Zhi-zhong Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


An improved, cost-effective, and one-pot method for the synthesis of benzoyl metronidazole was achieved by using 𝑁 , 𝑁 -carbonyldiimidazole as a coupling reagent. Moreover, the byproduct imidazole as the catalyst promoted the reaction. The procedures are simple and suitable to large-scale manufactures.