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Journal of Chemistry
Volume 2014, Article ID 260672, 7 pages
http://dx.doi.org/10.1155/2014/260672
Research Article

Cardioprotective Activity of , -Bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide Derivative against Doxorubicin Induced Cardiotoxicity in Rats

1Department of Pharmacology, Vaageswari College of Pharmacy, Rama Krishna Colony, Beside LMD Police Station, Karimnagar, Andhra Pradesh 505 481, India
2Department of Pharmaceutical Chemistry, Kakatiya Institute of Pharmaceutical Sciences, Pembarthy, Hasanparthy, Warangal 506 371, India
3Center for Pharmaceutical Sciences, IST, JNTU, Kukatpally, Hyderabad 500085, India
4Deparment of Pharmaceutics, SVS School of Pharmacy, SVS group of Institutions, Ramaram, Hanamkonda, Warangal 506 015, India
5Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506 009, India

Received 25 May 2013; Accepted 18 November 2013; Published 28 January 2014

Academic Editor: Isabel Seiquer

Copyright © 2014 Salma Tabassum et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present study was aimed at evaluating the cardioprotective effect of novel synthetic , -bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide derivative, by estimating the various biomarkers like creatine kinase-myoglobin (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), and triglycerides (TG) in plasma and antioxidants like catalase, superoxide dismutase in heart tissue homogenate, and histopathological examination of heart tissues. The results showed the significant ( ) dose dependent decrease in elevated cardiotoxic biomarkers CK-MB, LDH, AST, and TG levels. The histopathological studies of heart tissues showed mild degeneration of muscle bundles and less interstitial edematous changes. The results showed the significant ( ) dose dependent increase in antioxidant enzymes catalase and superoxide dismutase in heart tissue homogenates. These observations enable us to conclude that , -bis[5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene]carbonohydrazide has cardioprotective activity against doxorubicin induced cardiotoxicity.