Review Article

Toxicity and Microbial Degradation of Nitrobenzene, Monochloronitrobenzenes, Polynitrobenzenes, and Pentachloronitrobenzene

Table 1

Uses of nitrobenzene and its derivatives.

ChemicalUsesReferences

NitrobenzeneUsed for the production of aniline, which is the main source for the synthesis of polyurethane.
Synthesis of chemicals such as benzidine, quinoline, azobenzene, pyroxylin compounds, and isocyanates.
Synthesis of pesticides, rubbers, and pharmaceuticals.
Synthesis of dyes such as nigrosine and magenta.
Making greases and oils.
Preparation of soaps and shoe polishes.
Used as a solvent for cellulose ester in modifying esterification of cellulose acetate and in refining lubricating oils.
[1, 4ā€“6]

1,3-Dinitrobenzene (1,3-DNB)Used in explosives.
Formed as a by-product during the manufacture of the explosive, trinitrotoluene.
Used as a camphor substitute in nitrocellulose, a compound in explosives and propellants.
Used in the production of dyes and plastics.
Used as an organic intermediate for m-phenylenediamine, a chemical used in the synthesis of aramid fibers and spandex.
Used as an indicator in the detection of 17-ketosteroids.
Used as an electrolytic reducer in the preparation of aminocresols.
[4, 5]

1,3,5-Trinitrobenzene (1,3,5-TNB)Used as an explosive by a variety of industries and the military.
Used as a vulcanizing agent in the processing of natural rubber.
Used as an indicator in acid-base reactions in the pH range of 12.0ā€“14.0.
[3, 5]

4-Chloronitrobenzene (4CNB)Used for synthesis of chemicals such as p-nitrophenol, p-nitroaniline, p-aminophenol, 4-chloroaniline, 4-nitrophenol, 4-nitroanisole, para-anisidine, 4-nitroaniline, 6-chloro-3-nitrobenzenesulfonic acid, 2,4-dinitrochlorobenzene, 3,4-dichloronitrobenzene phenacetin, acetaminophen, and parathion.
Used for synthesis of agricultural chemicals, rubber chemicals, antioxidants, oil additives, and the drug, dapsone.
[5, 8]

2-Chloronitrobenzene (2CNB)Used for synthesis of para-anisidine, diaminophenol hydrochloride (a photographic developer), corrosion inhibitors, pigments, and other agricultural chemicals. [8]

3-Chloronitrobenzene (3CNB)Used for synthesis of 3-chloroaniline (orange GC base) [7]

PentachloronitrobenzeneUsed as an organochlorine fungicide for control of various fungal diseases caused by Rhizoctonia solani, Botrytis spp., Aspergillus spp., Penicillium spp., Fusarium spp., Sclerotinia spp., and Tilletia caries.
Used for soil and seed treatment against Rhizoctonia.
Used to inhibit slime formation in industrial water.
Inhibits mitotic/division and suppresses fungal sporulation.
[9, 10]