Journal of Chemistry / 2014 / Article / Tab 2

Review Article

Pharmacological Activities of Sijunzi Decoction Which Are Related to Its Antioxidant Properties

Table 2

Antioxidant ingredientStructure of compoundPharmacological activityReferences

Paeonol278318.table.002a(1) Antioxidant and anti-inflammatory properties
(2) Treatment for vascular disorders
(3) Protection against atherosclerosis.
(4) Neuroprotection
(5) Protection against hypoxia/reoxygenation damage
(6) Growth-inhibitory and apoptosis-inducing effects on cancer cells
[912, 1821]

Dauricine278318.table.002b(1) Inhibition of neuron apoptosis
(2) Induction of glutathione depletion and apoptosis in cancer cells
(3) Inhibition of tumor cell proliferation
(4) Inhibition of cancer angiogenesis
(5) Induction of tumor cell apoptosis

Pancratistatin278318.table.002c(1) Increased reactive oxygen species (ROS) production
(2) Induction of mitochondrial membrane collapse
(3) Potential induction of tumor apoptosis
(4) Reduction of tumor growth

Isoliquiritigenin278318.table.002d(1) Cardioprotection against ischemic injury
(2) Decreased blood glucose level
(3) Prevention of neurodegenerative diseases
(4) Prevention of neuronal apoptotic death
(5) Repression of liver X receptor-α-dependent hepatic steatosis
(6) Induction of apoptosis
(7) Inhibition of cancer cell proliferation
(8) Enhancement of HepG2 cell radiosensitivity
[3, 13, 3138]

Naringin278318.table.002e(1) Inhibition of ROS-activated MAPK pathway
(2) Antihypertensive and antithrombotic effects
(3) Protection of endothelial function from ROS
(4) Protection against myocardial ischemia reperfusion injury
(5) Antidiabetic effect
(6) Decreased inflammatory cell infiltration
(7) Neuroprotective effect
(8) Anti-inflammatory effect
(9) Protection against pulmonary fibrosis
(10) Induction of cancer cell apoptosis
(11) Attenuation of chronic pulmonary neutrophilic inflammation
(12) Mitigation of erythrocyte aging
[46, 14, 15, 3947]

Glabridin278318.table.002f(1) Antioxidation
(2) Protection against obesity-related metabolic disorders
(3) Neuroprotective effect
(4) Anti-inflammatory effect
(5) Anticancer effect
[7, 16, 17, 48, 49]

Isorhamnetin278318.table.002g(1) Inhibition of ROS-induced apoptotic pathway
(2) Anti-ROS-induced cardiomyopathy
(3) Protection of hepatocytes against oxidative stress
(4) Antioxidant and antiproliferative effects
(5) Modulation of the peroxisome proliferator-activated receptor pathway in gastric cancer
[8, 5054]

Calycosin278318.table.002h(1) Neuroprotection
(2) Inhibition of breast cancer growth
[55, 56]

Pinocembrin278318.table.002i(1) Neurovascular protection
(2) Protection of cerebral ischemia
(3) Increased viability and mitochondrial membrane potential of cultured rat cerebral microvascular endothelial cells
(4) Protection of rat brain against oxidation and apoptosis
(5) Abrogation of neurotoxin effects
(6) Improvement of rat cognitive impairments
(7) Anticarcinogenic effects
(8) Triggering mitochondrial apoptosis in cancer cells

Nicotiflorin278318.table.002j(1) Improvement of brain infarct volume and neurological deficits
(2) Protection against memory dysfunction, energy metabolism failure, and oxidative stress
(3) Protection against cerebral ischemic damage

Liquiritigenin278318.table.002k(1) Improvement of behavioral performance and attenuation of neuronal loss in the brain
(2) Protection of human lung cells (A549)
(3) Choleretic effect and induction of hepatic transporters and phase-II enzymes
(4) Induction of apoptosis in the mitochondrial pathway
(5) Anti-inflammatory effect
(6) Protection of osteoblast against cytotoxicity

Kaempferol278318.table.002l(1) Attenuation of neuronal toxicity
(2) Inhibition of monoamine oxidase and excessive NO production

Licoflavone278318.table.002m(1) Suppression of gastric mucosa injury[69]

Isobavachalcone278318.table.002n(1) Antioxidant effects on rat liver microsomes and mitochondria
(2) Induction of neuroblastoma apoptosis
[70, 71]

Morusin278318.table.002o(1) Anticancer properties[72, 73]

Licochalcone A278318.table.002p(1) Antitumor and antimetastatic properties
(2) Apoptosis-promotion
(3) Inhibition of inflammatory cytokines and ROS production

Licochalcone B278318.table.002q(1) Inhibition of cancer cell proliferation [77]

Rutin278318.table.002r(1) Inhibition of primary humoral immune response [78]

Quercetin278318.table.002s(1) Antiliver fibrosis properties
(2) Modulation of degranulation and oxidative burst
[54, 69, 79]

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