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Journal of Chemistry
Volume 2014, Article ID 353797, 4 pages
Research Article

Modification of Thionucleobases in Ionic Liquids

1School of Life and Science, Northeast Agricultural University, Harbin 150030, China
2Heilongjiang Academy of Agricultural Sciences, Harbin 150086, China

Received 15 August 2014; Accepted 22 September 2014; Published 21 October 2014

Academic Editor: Joaquin Campos

Copyright © 2014 Xiaomei Hu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A simple method was established for the preparation of thio-substituted thionucleobases using room temperature ionic liquids (RTILs) such as 1-butyl-3-methylimidazolium trifluoroacetate [BMIM]+[CF3COO] and 1-methoxyethyl-3-methylimidazolium trifluoroacetate [MeOEtMIM]+[CF3COO] as solvents and catalysts without any other catalyst. These reactions proceeded efficiently in RTILs with excellent yield of products. RTILs can be recycled and reused effectively without further purification.