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Journal of Chemistry
Volume 2014 (2014), Article ID 378567, 10 pages
Research Article

Synthesis, Spectral Characterization, Magnetic Moment, Mass, X-Ray Diffraction, and Kinetic (TGA) Studies of Cr(III) Complex with Metformin: An Oral Antidiabetic Drug

1Department of Chemistry, Saifia Science College, Barkatullah University, Bhopal 462001, India
2Department of Chemistry, Crescent College of Technology, Nabi Bagh, Karond, Bhopal 462038, India

Received 11 May 2013; Accepted 16 December 2013; Published 18 February 2014

Academic Editor: Tanaji Talele

Copyright © 2014 Bal Krishan and S. A. Iqbal. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The present work describes synthesis, spectral characterization, and X-ray diffraction studies of Cr(III) with “metformin,” an oral antidiabetic drug. The conductometric titration using monovariation method indicates that complex is ionic and of L2M type. Analytical data agree with the molecular formula of complex namely, [(C4H11N5)2Cr(H2O)2]2Cl. Geometry of complex assigned is octahedral, supported by IR, electronic spectra, magnetic moments, 1H-NMR and mass studies, and proposed structure (I) for complex. X-ray diffraction data also supports the complex formation and symmetry of complex and various parameters like particle size, porosity, volume of unit cell, and density have been calculated. The Freeman-Carroll and Sharp-Wentworth methods have been used to calculate activation energy and thermal stability. The activation energy calculated with the help of these methods are in agreement with each other. Thermodynamic parameters such as free energy change (Δ) and entropy change are also determined on the basis of TG curves and by using data of the Freeman-Carroll method.