Design and Synthesis of an Indole-Estrogen Derivative

Figure 3

Synthesis of 3-(4-azidocarbonyl-phenoxy)-NH-indolo[2′,3′:17,16]estra-1,3,5(10)-triene (7). The first stage was achieved by the reaction of 5 with hydrofluoric acid (iv) to form compound 6 (NH-indolo[2′,3′:17,16]estra-1,3,5(10)trien-3-ol). In addition, 6 was made reacting with -nitrobenzoyl azide for synthesis of 7. (v) = dimethyl sulfoxide.