TY - JOUR A2 - Onul, Nihal AU - Kheder, Nabila A. AU - Mabkhot, Yahia N. AU - Zahian, Fawzia R. AU - Mohamed, Sara S. PY - 2014 DA - 2014/03/10 TI - Regioselective Synthesis of Some Pyrazole Scaffolds Attached to Benzothiazole and Benzimidazole Moieties SP - 581721 VL - 2014 AB - Condensation of 2-(benzothiazol-2-yl)acetonitrile (1) or 2-(1-methyl-1H-benzimidazol-2-yl)acetonitrile (2) with thiophene-2-carbaldehyde afforded the corresponding acrylonitrile derivatives 3 or 4, respectively. The 1,3-dipolar cycloaddition reaction of the acrylonitrile 3 or 4 with nitrile-imine 6 gave novel pyrazole derivatives pendant to benzothiazole and benzimidazole. The pyrazoline derivative 7 was converted into the corresponding pyrazole derivative 11 via thermal elimination of hydrogen cyanide upon heating in sodium ethoxide solution. The structures of the synthesized products were confirmed by IR, 1H NMR, and mass spectral techniques. SN - 2090-9063 UR - https://doi.org/10.1155/2014/581721 DO - 10.1155/2014/581721 JF - Journal of Chemistry PB - Hindawi Publishing Corporation KW - ER -