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Journal of Chemistry
Volume 2014, Article ID 681364, 9 pages
Research Article

Synthesis and Biological Activities of Some Novel (E)-Alpha-(methoxyimino)benzeneacetate Derivatives with Modified 1,2,4-Triazole Moiety

1College of Quality and Technical Supervision, Hebei University, Baoding 071002, China
2Institute of Plant Protection and Soil Fertilizer, Hubei Academy of Agricultural Science, Wuhan 430064, China

Received 6 June 2014; Revised 23 July 2014; Accepted 26 July 2014; Published 24 August 2014

Academic Editor: Gabriel Navarrete-Vazquez

Copyright © 2014 Xianyou Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To find new strobilurin analogues with high activity against resistant pathogens, a series of (E)-α-(methoxyimino)benzeneacetate derivatives containing 1,2,4-triazole Schiff base side chain were designed and synthesized. Their structures were confirmed by IR, 1H NMR, and 13C NMR, ESI-HRMS, or elemental analyses. Bioassays indicated that most of the target compounds showed moderate to good fungicidal activities against Rhizoctonia solani, Botrytis cinerea Pers., Fusarium graminearum, Cotton rhizoctoniosis, and Blumeria graminis. For example, compounds 6g and 6j exhibited promising antifungal activity against Rhizoctonia solani, Botrytis cinerea Pers., and Fusarium graminearum. Compounds 6c, 6l, and 6m had higher fungicidal activities against Blumeria graminis at the concentration of 50 µg/mL; inhibitory rate is 91.41%, 92.13%, and 91.77%, respectively.