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Journal of Chemistry
Volume 2014, Article ID 748680, 8 pages
Research Article

Stability of Positively Charged Nanoemulsion Formulation Containing Steroidal Drug for Effective Transdermal Application

1Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia
2Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia
3Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia

Received 22 July 2013; Revised 15 April 2014; Accepted 23 April 2014; Published 15 July 2014

Academic Editor: Isabel Seiquer

Copyright © 2014 Stephanie Da Costa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This paper emphasizes the formation of a positively charged nanoemulsion system for steroid drugs (hydrocortisone). It is believed that positively charged nanoemulsion provides more effective penetration of the skin. Therefore in our study we focused on the incorporation of phytosphingosine which serves as a positively charged cosurfactant in the nanoemulsion system. Negatively charged nanoemulsions were formulated mainly for comparison. Freshly prepared formulations were formed with particle size less than 300 nm and showed good stability over time. The oil-in-water nanoemulsion also showed good viscosity, conductivity, and pH values. From TEM micrograph, particle size showed consistent results with the measurement using photon correlation spectroscopy. It was concluded that both positively and negatively charged nanoemulsions showed good stability and have great potential in transdermal delivery system. Though, further investigation of the drug release and drug penetration of both positively and negatively charged nanoemulsions will be studied to further prove the efficacy of nanoemulsion with hydrocortisone as a delivery system for dermal application.