Stability of Positively Charged Nanoemulsion Formulation Containing Steroidal Drug for Effective Transdermal Application

The mean particle size of hydrocortisone loaded NEC with different solvent over a period of 3 m. (0 week refers to freshly prepared nanoemulsion). C(IPA): 24.5% water, 10% palm kernel oil esters (PKOEs), 24% Lipoid S75, 16% Tween 20, 24% IPA 1.0% hydrocortisone, and 0.5% phenonip; C(EtOH): 24.5% water, 10% palm kernel oil esters (PKOEs), 24% Lipoid S75, 16% Tween 20, 24% EtOH, 1.0% hydrocortisone, and 0.5% phenonip; C(IPA) 1.6% PS: 22.9% water, 10% palm kernel oil esters (PKOEs), 24% Lipoid S75, 16% Tween 20, 24% IPA, 1.6% phytosphingosine, 1.0% hydrocortisone; and 0.5% phenonip C(EtOH) 1.6% PS: 22.9% water, 10% palm kernel oil esters (PKOEs), 24% Lipoid S75, 16% Tween 20, 24% IPA, 1.6% phytosphingosine, 1.0% hydrocortisone, and 0.5% phenonip.