Research Article
Stability of Positively Charged Nanoemulsion Formulation Containing Steroidal Drug for Effective Transdermal Application
Table 1
Compositions of nanoemulsions used in this study.
| | Compound | Content (wt.%) | | Positively charged | Negatively charged | | C(IPA) | C(EtOH) | C(IPA) | C(EtOH) |
| | Oil phase | | | | | | Palm kernel oil ester | 10 | 10 | 10 | 10 | | (PKOEs) | 24 | 24 | 24 | 24 | | Lipoid S-75 | 24 | 24 | 24 | 24 | | Isopropanol (IPA) | 24 | — | 24 | — | | Ethanol (EtOH) | — | 24 | — | 24 | | Hydrocortisone | | | | | | Phytosphingosine | 0.4, 0.8, | 0.4, 0.8, | — | — | | 1.2, 1.6, | 1.2, 1.6, | | | | 2.0 | 2.0 | | | | Water phase | | | | | | Tween 20 | 16 | 16 | 16 | 16 | | Preservative | 0.5 | 0.5 | 0.5 | 0.5 | | Water to | 100 | 100 | 100 | 100 |
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C(IPA): nanoemulsion with isopropanol.
C(EtOH): nanoemulsion with isopropanol.
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