Design and Synthesis of Two Oxazine Derivatives Using Several Strategies

Figure 6

Synthesis of 2-chloro-3-{{2-[(3-chloro-2-oxo-cyclobutyl)-(1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl)-amino]-ethyl}-[1,5-dimethyl-4-(1H-naphtho[1,2-e][1,3]oxazin-2-yl)-2-phenyl-2,3-dihydro-1H-pyrazol-3-yl]-amino}-cyclobutanone (12). Reaction of N-[1,5-dimethyl-4-(1H-naphtho[1,2-e][1,3]oxazin-2-yl)-2-phenyl-1,2-dihydro-pyrazol-3-yli dene]-N′-(1,7,7-trimethyl-bicyclo[2.2.1]hept-2-ylidene)ethane-1,2-diamine (11) with chloroacetyl chloride (8) to form the compound 12. v: triethylamine/rt.