Synthesis, Crystal Structure, and Biological Activity of <i>cis/trans</i> Amide Rotomers of (<i>Z</i>)-<i>N</i>′-(2-Oxoindolin-3-ylidene)formohydrazide

<table><sup>1</sup>H NMR (DMSO-<svg height="13.1057pt" id="M24" style="vertical-align:-3.427799pt" version="1.1" viewbox="-0.0498162 -9.6779 12.7131 13.1057" width="12.7131pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0135,0,0,-0.0135,0,0)"><path d="M530 686C535 705 530 712 521 712C504 712 448 684 359 674L358 648H393C437 648 439 646 429 593L400 435C372 447 345 448 332 448C286 448 194 414 144 373C68 311 23 203 23 111C23 26 57 -12 91 -12C120 -12 147 3 188 29C227 54 290 102 341 170H343L322 71C308 6 320 -12 341 -12C373 -12 442 27 501 96L485 120C455 91 422 67 408 67C401 67 401 76 404 91C440 294 479 473 530 686ZM387 375L355 241C326 187 200 53 142 53C126 53 109 73 109 130C109 217 154 337 218 381C240 396 265 404 297 404S372 390 387 375Z" id="g113-101"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="555" vert-adv-y="555"></glyph.data></g><g transform="matrix(.0095,0,0,-0.0095,7.452,3.264)"><path d="M141 347C171 480 264 541 327 570C364 587 403 599 436 605L429 641C389 634 339 622 300 609C191 570 37 458 37 239C37 86 126 -12 245 -12C367 -12 454 89 454 210C454 314 380 397 272 397C252 397 230 390 208 380L141 347ZM231 338C323 338 366 257 366 174C366 108 340 27 263 27C180 27 129 123 129 244C129 268 130 292 135 310C158 323 193 338 231 338Z" id="g50-55"></path><glyph.data ascent="3443" descent="-2856" horiz-adv-x="487" vert-adv-y="487"></glyph.data></g></svg>) of compound<b> 2</b>.</table>

Journal of Chemistry

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Figure 2

Figure 2: Synthesis, Crystal Structure, and Biological Activity of <i>cis/trans</i> Amide Rotomers of (<i>Z</i>)-<i>N</i>′-(2-Oxoindolin-3-ylidene)formohydrazide 

Journal of Chemistry

Synthesis, Crystal Structure, and Biological Activity of cis/trans Amide Rotomers of (Z)-N′-(2-Oxoindolin-3-ylidene)formohydrazide

Figure 2