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Journal of Chemistry
Volume 2014, Article ID 956278, 7 pages
Research Article

Flavonoids Extraction from Taraxacum officinale (Dandelion): Optimisation Using Response Surface Methodology and Antioxidant Activity

1State Key Laboratory of Generic Pharmaceutical Technology for Traditional Chinese Medicine, Linyi 276006, China
2Chemical Engineering and Pharmaceutical College, Henan University of Science and Technology, Luoyang 471003, China

Received 23 January 2014; Accepted 8 July 2014; Published 4 August 2014

Academic Editor: Kequan Zhou

Copyright © 2014 Zongxi Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The Box-Behnken design combined with response surface method was employed to optimize ultrasonic-assisted extraction of flavonoids from Taraxacum officinale. The optimized results showed that the highest extraction yield with ultrasonic-assisted extraction could reach 2.62% using 39.6% (v/v) ethanol and 59.5 : 1 (mL/g) liquid-solid ratio for 43.8 min. The crude extract was then purified by HPD-100 macroporous adsorption resin, and the flavonoids content in the purified extract increased to 54.7%. The antioxidant activity of the purified flavonoids was evaluated in vitro by scavenging capacity of ABTS or DPPH, β-carotene bleaching, and FTC test. The knowledge obtained from this study should be useful to further develop and apply this plant resource.