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Journal of Chemistry
Volume 2015 (2015), Article ID 241243, 4 pages
http://dx.doi.org/10.1155/2015/241243
Research Article

Antifungal Activity of Coumarin Mammeisin Isolated from Species of the Kielmeyera Genre (Family: Clusiaceae or Guttiferae)

1Chemistry Department, Federal University of Ouro Preto, Morro do Cruzeiro, 34500-000 Ouro Preto, MG, Brazil
2Department of Biochemistry, Federal University of Viçosa, 36570-900 Viçosa, MG, Brazil
3Institute of Biological Sciences, Federal University of Pará, 66075-110 Belém, PA, Brazil

Received 24 July 2014; Revised 3 November 2014; Accepted 28 January 2015

Academic Editor: Kamel H. Shaker

Copyright © 2015 Helcio Cassemiro Marcondes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Coumarin mammeisin isolated from Kielmeyera elata was evaluated for its toxicity and antifungal activities. The toxicity of mammeisin was investigated by utilizing the Artemia salina methodology to determine its LD50 value. The minimum inhibitory concentration (MIC) of fungi Candida sp. was assessed for mammeisin, presenting equivalent activity to ketoconazole but displaying better results than fluconazole.