Antifungal Activity of Coumarin Mammeisin Isolated from Species of the Kielmeyera Genre (Family: Clusiaceae or Guttiferae)

Table 1

Summary of the minimum inhibitory concentration (MIC) for mammeisin and two antifungal agents.

(a)

Candida	ATCC	Mammeisin (CIM)	Ketoconazole (CIM)	Fluconazole (CIM)
C. albicans	2209	512 μg/mL	2 μg/mL	8 μg/mL
C. tropicalis	750	512 μg/mL	512 μg/mL	—
C. parapsilosis	2209	512 μg/mL	2 μg/mL	8 μg/mL
C. krusei	6258	512 μg/mL	2 μg/mL	64 μg/mL

(b)

—

12

11

10

9

8

7

6

5

4

3

2

1

—

C. albicans

∗

∗

∗

∗

∗

∗

∗

∗

∗

∗

∗

∗

A

C. tropicalis

∗

∗

∗

∗

∗

∗

∗

∗

∗

∗

∗

∗

B

C. parapsilosis

∗

∗

∗

∗

∗

∗

∗

∗

∗

∗

∗

∗

C

C. krusei

∗

∗

∗

∗

∗

∗

∗

∗

∗

∗

∗

∗

D

C. albicans

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

E

C. tropicalis

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

F

C. parapsilosis

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

G

C. krusei

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

∗∗

H

—

C−

512

256

128

64

32

16

8

4

2

1

C+

—

Mammeisin.
^∗∗Antifungal standard (ketoconazole/fluconazole).
C+: positive control.
C−: negative control.