Table of Contents Author Guidelines Submit a Manuscript
Journal of Chemistry
Volume 2015, Article ID 245625, 6 pages
http://dx.doi.org/10.1155/2015/245625
Research Article

Synthesis and Characterization of Novel Copolymeric Resveratrol Conjugates

1School of Pharmacy, CHIRI Biosciences, Curtin University, Bentley, WA 6102, Australia
2Department of Chemistry, Curtin University, Bentley, WA 6102, Australia

Received 28 December 2014; Accepted 23 February 2015

Academic Editor: Albert Demonceau

Copyright © 2015 Yan-Jing Ng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Resveratrol (RSV), naturally found in plants, is known to have health benefits and has been proposed as a potential anticancer and cardioprotective drug. However, due to its molecular structure, it undergoes rapid metabolism in the body resulting in low bioavailability. Novel polymeric methoxy-poly(ethylene glycol)-block-poly(ε-caprolactone) (mPEG-PCL) RSV conjugates with varying PCL chain lengths have been synthesised and formulated into micelles and/or nanoparticles for preliminary in vitro stability studies. RSV conjugated with mPEG2000-PCL9500 was found to have improved solubility and stability of RSV as compared to RSV alone. The length of the PCL chain was found to affect the micelle formation, hence the stability in physiological buffers and rat plasma.