Synthesis and Characterization of Novel Copolymeric Resveratrol Conjugates

Table 4

Chemical stability of conjugates in physiological buffer at 24 h and rat plasma.

Polymeric conjugate	MilliQ water	Acetate buffer pH 4.5	Phosphate buffer pH 7.2	in rat plasma (min)
mPEG2000-glu-RSV	>65%^*	>95%	>40%	3
mPEG2000-CL-glu-RSV	>80%	>95%	>95%	5
mPEG2000-PCL300-glu-RSV	n/d^**	n/d	n/d	3
mPEG2000-PCL550-glu-RSV	n/d	n/d	n/d	3
mPEG2000-PCL1300-glu-RSV	n/d	n/d	n/d	3.5
mPEG2000-PCL5100-glu-RSV	>80%	>80%	>85%	4
mPEG2000-PCL9500-glu-RSV	>95%	>90%	>90%	10
mPEG2000-PCL13000-glu-RSV	>35%	>30%	>40%	8

Value represents percentage of original concentration at 24 h; ^**n/d: no data.