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Journal of Chemistry
Volume 2015, Article ID 376527, 7 pages
http://dx.doi.org/10.1155/2015/376527
Research Article

Design, Synthesis, and In Vitro Antiplatelet Aggregation Activities of Ferulic Acid Derivatives

Jiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Jiangsu Key Laboratory for High Technology Research of TCM Formulae, and National and Local Collaborative Engineering Center of Chinese Medicine Resources, Nanjing University of Chinese Medicine, Nanjing 210023, China

Received 31 January 2015; Revised 15 March 2015; Accepted 15 March 2015

Academic Editor: Maria N. D. S. Cordeiro

Copyright © 2015 Peng-Xuan Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In order to discover new compounds with antiplatelet aggregation activities, some ferulic acid (FA) derivatives were designed and synthesized. The in vitro antiplatelet aggregation activities of these compounds were assessed by turbidimetric test. The results showed that the target compound 7f had potent antiplatelet aggregation activity with its IC50 27.6 μmol/L, and 7f can be regarded as a novel potent antiplatelet aggregation candidate.