Studies on the Protective Effects of Scutellarein against Neuronal Injury by Ischemia through the Analysis of Endogenous Amino Acids and Ca2+ Concentration Together with Ca2+-ATPase Activity
Table 1
Effects of scutellarein on contents of 17 amino acid neurotransmitters in brain of cerebral ischemic/reperfusion rats (μg/g, , ).
Analyte
Sham
Model
Scutellarein
Scutellarein
Scutellarein
(μg/g)
(μg/g)
(0.09 mmol/kg)
(0.17 mmol/kg)
(0.35 mmol/kg)
GABA
111.6 ± 0.2579
119.9 ± 0.8276△△
121.8 ± 1.263
124.1 ± 1.191
135.9 ± 6.187
Gly
3.332 ± 0.1681
4.607 ± 0.2127△
3.863 ± 0.1112
3.961 ± 0.2612
3.558 ± 0.1295
Glu
42.66 ± 4.420
85.52 ± 5.436△
69.72 ± 3.356
68.95 ± 11.10
61.80 ± 4.438
Tau
55.86 ± 3.225
96.11 ± 2.247△△
81.11 ± 2.153
91.54 ± 3.421
112.1 ± 5.386
Asp
2.413 ± 0.3432
5.214 ± 0.2840△△
4.737 ± 0.2623
3.641 ± 0.2933
3.133 ± 0.2145
Leu
11.35 ± 1.211
21.84 ± 1.342△△
19.93 ± 0.8321
17.73 ± 1.231
15.50 ± 2.320
Met
3.432 ± 0.1210
5.041 ± 0.2140△△
4.897 ± 0.3254
3.845 ± 0.0231
3.792 ± 0.1100
Phe
10.08 ± 2.113
18.92 ± 2.513
16.85 ± 2.653
15.71 ± 1.216
12.53 ± 0.3245
Ala
18.78 ± 2.165
25.52 ± 3.245△
23.10 ± 0.4265
24.17 ± 3.254
20.00 ± 0.6530
Cit
1.813 ± 0.2311
2.562 ± 0.4301△
2.391 ± 0.1254
2.122 ± 0.4322
2.023 ± 0.3251
Gln
107.1 ± 3.248
140.7 ± 1.342△
134.5 ± 6.231
126.4 ± 4.563
117.0 ± 3.258
Asn
3.072 ± 0.1281
4.713 ± 0.4381△
4.391 ± 0.4351
3.472 ± 0.1043
3.533 ± 0.2549
Ser
27.13 ± 1.151
29.44 ± 1.432
28.57 ± 4.324
28.95 ± 3.980
28.38 ± 1.543
Val
8.201 ± 0.3505
9.192 ± 0.5319△
9.013 ± 0.5600
8.912 ± 0.5341
8.732 ± 0.4533
H-pro
2.301 ± 0.2321
3.303 ± 0.5432△
3.122 ± 0.1120
2.821 ± 0.2004
2.573 ± 0.1043
Lys
1.562 ± 0.2210
4.071 ± 0.2311△△
3.832 ± 0.1240
3.553 ± 0.1043
2.231 ± 0.2034
Arg
4.582 ± 0.1211
10.65 ± 0.3218△
8.831 ± 0.5421
8.262 ± 0.5902
6.801 ± 0.6420
Model groups compared with their sham groups, respectively (, ), compared with model groups (, ).
