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Journal of Chemistry
Volume 2015, Article ID 982404, 6 pages
http://dx.doi.org/10.1155/2015/982404
Research Article

Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives

1Laboratoire de Chimie Organique Hétérocyclique URAC 21, Faculté des Sciences, Université Mohammed V, Rabat, Morocco
2Medicinal Chemistry Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, 10170 Rabat, Morocco
3Laboratoire de Physico-Chimie des Matériaux Inorganiques et Organiques (LPCMIO), ENS, Rabat, Morocco
4Laboratoire de Biochimie et Immunologie, Faculté des Sciences, Université Mohammed V, Rabat, Morocco

Received 24 February 2015; Revised 16 April 2015; Accepted 20 April 2015

Academic Editor: Marco Radi

Copyright © 2015 Mohammed El Fal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

New heterocyclic compounds spiroderivatives of allopurinol of biological interest were prepared from allopurinol via thionation and 1,3-dipolar cycloaddition and were produced in high to excellent yields. These compounds were characterized on the basis of spectral and spectroscopic data (1H NMR, 13C, IR, and MS). The antibacterial activity of the synthesized products was studied using bacterial strains: Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa. Compounds having an ethyl group showed the best activity with MIC value of 31.25 µg/mL against Staphylococcus aureus and Streptococcus fasciens.