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Journal of Chemistry
Volume 2016, Article ID 1739879, 7 pages
Research Article

A Simple and Convenient Method for Simultaneous Determination of Schizandrol A, Schizandrol B, Schisandrin A, γ-Schisandrin, and Schisandrin C

1Sino-German Joint Research Institution, Nanchang University, 235 Nanjing East Road, Nanchang 330047, China
2Bureau of Agriculture and Grain of Ganzhou, Changzheng Road, The Municipal Building, Zhanggong District, Ganzhou 341000, China

Received 21 March 2016; Revised 23 May 2016; Accepted 19 July 2016

Academic Editor: Pranav S. Shrivastav

Copyright © 2016 Yu Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A simple, rapid, and specific HPLC method was established for simultaneous determination of five major lignans (Schizandrol A, Schizandrol B, Schisandrin A, γ-Schisandrin, and Schisandrin C) in Schisandra chinensis. The five lignans can be separated completely on Kromasil C18 column (250 nm × 4.6 nm) and then detected at 254 nm using methanol (mobile phase A) and water (mobile phase B) with gradient elution as the mobile phase at 1.0 mL/min flow rate. The column temperature was 30°C. The method was validated in terms of linearity, precision, stability, repeatability, and recovery. Results showed that the method is accurate and reproducible.