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Journal of Chemistry
Volume 2016 (2016), Article ID 2082946, 5 pages
http://dx.doi.org/10.1155/2016/2082946
Research Article

α-Amylase and α-Glucosidase Inhibitory Saponins from Polyscias fruticosa Leaves

Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam

Received 21 February 2016; Accepted 17 April 2016

Academic Editor: Nick Kalogeropoulos

Copyright © 2016 Tran Thi Hong Hanh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Three bisdesmosidic saponins 3-O-[β-D-glucopyranosyl-(14)-β-D-glucuronopyranosyl] oleanolic acid 28-O-β-D-glucopyranosyl ester (1), polyscioside D (2), and 3-O--D-glucopyranosyl-(12)-[β-D-glucopyranosyl-(14)]-β-D- oleanolic acid 28-O-β-D-glucopyranosyl-(12)-β-D-galactopyranosyl ester (3) were isolated from a methanol extract of Polyscias fruticosa (L.) Harms leaves. Compound 1 was obtained as a main constituent and compound 3 was reported for the first time and named as polyscioside I. Saponin 1 inhibited porcine pancreas α-amylase and yeast α-glucosidase activities while 2 and 3 were inactive. Synergistic inhibitory effect on α-amylase was observed from the combination of low concentrations of 1 and acarbose. The findings suggest the use of P. fruticosa and its major saponin 1 for the prevention and treatment of diabetes and its complications.