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Journal of Chemistry
Volume 2016, Article ID 2510621, 6 pages
Research Article

Baicalin and Baicalein Inhibit Src Tyrosine Kinase and Production of IL-6

1Fidelta Ltd., Prilaz Baruna Filipovića 29, 10000 Zagreb, Croatia
2Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Universitaetsplatz 4/1, 8010 Graz, Austria
3Department of Pharmacognosy, Faculty of Pharmacy and Biochemistry, University of Zagreb, Marulićev Trg 20/II, 10000 Zagreb, Croatia
4Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16 Nanxiaojie, Dongzhimennei Avenue, Dongcheng District, Beijing 100700, China

Received 26 October 2015; Revised 23 February 2016; Accepted 2 March 2016

Academic Editor: Gabriel Navarrete-Vazquez

Copyright © 2016 Dubravko Jelić et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Flavonoids play an important role in the treatment of various diseases, as they are able to inhibit reactive oxygen species, which cause damage to cells and tissues which may lead to increased risk of inflammatory diseases. Baicalin and baicalein, two flavonoids found in the roots of Scutellaria baicalensis, in the leaves of Thymus vulgaris and Oroxylum indicum, were tested for their anti-inflammatory activity as well as for their cytotoxicity. Thereby the two compounds were investigated on Src tyrosine kinase inhibition and inhibition of production of interleukin (IL-6) in lipopolysaccharide- (LPS-) stimulated THP-1 cells. Additionally, the THP-1 cell line was used for the determination of the cytotoxicity. Both baicalin and baicalein showed some anti-inflammatory properties, while baicalein turned out to be the more active compound with higher inhibitory activities on both Src tyrosine kinase and production of cytokine IL-6. Baicalin and baicalein showed no signs of cytotoxicity in the MTS cytotoxicity assay in THP-1 cells.