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Journal of Chemistry
Volume 2016, Article ID 2672740, 15 pages
Review Article

Hybrid Nanomaterials Based on Iron Oxide Nanoparticles and Mesoporous Silica Nanoparticles: Overcoming Challenges in Current Cancer Treatments

1Department of Science and Technology, Inter American University of Puerto Rico, Ponce Campus, Ponce, PR 00716, USA
2Department of Chemistry, The University of North Carolina at Charlotte, Charlotte, NC 28223, USA
3The Center for Biomedical Engineering and Science, The University of North Carolina at Charlotte, Charlotte, NC 28223, USA

Received 26 February 2016; Accepted 11 April 2016

Academic Editor: Dennis Douroumis

Copyright © 2016 Merlis P. Alvarez-Berríos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The current approaches used for the treatment of cancer face some clinical limitations such as induction of severe side effects, multidrug resistance (MDR), and low specificity toward metastatic cancer cells. Hybrid nanomaterials hold a great potential to overcome all these challenges. Among hybrid nanoparticles, those based on mesoporous silica and iron oxide nanoparticles (MSNs and IONPs) have gained a privileged place in the biomedical field because of their outstanding properties. There are many studies demonstrating their effectiveness as drug delivery systems, nanoheaters, and imaging contrast agents. This review summarizes the advances related to the utilization of IONPs and MSNs for reducing side effects, overcoming MDR, and inhibiting metastasis. Furthermore, we give a future perspective of the clinical application of these technologies.