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Journal of Chemistry
Volume 2016, Article ID 4068641, 8 pages
http://dx.doi.org/10.1155/2016/4068641
Research Article

Theoretical Study of Phosphoethanolamine: A Synthetic Anticancer Agent with Broad Antitumor Activity

1Postgraduate Program in Natural Products and Synthetic Bioactive, Federal University of Paraíba, 58051-900 João Pessoa, PB, Brazil
2Federal Institute of Sertão Pernambucano, 56314-520 Petrolina, PE, Brazil
3Laboratory of Synthesis and Vectorization of Molecules, State University of Paraíba, 58020-540 João Pessoa, PB, Brazil

Received 4 February 2016; Revised 24 April 2016; Accepted 7 June 2016

Academic Editor: Antreas Afantitis

Copyright © 2016 Vitor Prates Lorenzo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cancer is a major public health problem with limited success of available treatments, pointing to the need for new strategies to be developed. Phosphoethanolamine exhibits broad antitumor activity in a variety of tumor cells and potent inhibitor effects on tumor progress in vivo. Once-used organophosphates inhibit acetylcholinesterase (AChE), resulting in toxic effects to the user. As this group is present in phosphoethanolamine, we perform prediction of the in silico metabolism of phosphoethanolamine and submit this series to a docking study on AChE. A total of 10 metabolites were indicated by the prediction, including ammonia and hydroxylamine, which were not included in the study. Using a group of 8 organophosphorus whose pIC50 values ranged from 5.92 to 9.47 as template, we observed that no compound present in the phosphoethanolamine series had a binding energy lower than that of organophosphorus, suggesting that the series has low inhibitory power on AChE. In light of this, we conclude that phosphoethanolamine and its predicted metabolites do not significantly inhibit AChE to cause a cholinergic crisis. This finding highlights the importance of investigating this compound as lead for potential anticancer agents.