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Journal of Chemistry
Volume 2016, Article ID 5129010, 12 pages
http://dx.doi.org/10.1155/2016/5129010
Research Article

Synthesis, Biological, and Quantum Chemical Studies of Zn(II) and Ni(II) Mixed-Ligand Complexes Derived from N,N-Disubstituted Dithiocarbamate and Benzoic Acid

1Department of Chemistry, Federal University Ndufu-Alike Ikwo (FUNAI), PMB 1010, Abakaliki, Ebonyi, Nigeria
2Material Science Innovation and Modelling (MaSIM) Research Focus Area, Faculty of Agriculture, Science and Technology, North-West University, Mafikeng Campus, Private Bag Box X2046, Mmabatho 2735, South Africa
3Department of Chemistry, School of Mathematical and Physical Sciences, Faculty of Agriculture, Science and Technology, North-West University, Mafikeng Campus, Private Bag Box X2046, Mmabatho 2735, South Africa
4Inorganic Unit, Department of Chemistry, University of Ibadan, Oyo State, Nigeria
5Department of Chemistry, Faculty of Science, Obafemi Awolowo University, Ife 220005, Nigeria

Received 22 January 2016; Revised 29 February 2016; Accepted 1 March 2016

Academic Editor: Josefina Pons

Copyright © 2016 Anthony C. Ekennia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Some mixed-ligand complexes of Zn(II) and Ni(II) derived from the sodium salt of N-alkyl-N-phenyl dithiocarbamate and benzoic acid have been prepared. The complexes are represented as ZnMDBz, ZnEDBz, NiMDBz, and NiEDBz (MD: N-methyl-N-phenyl dithiocarbamate, ED: N-ethyl-N-phenyl dithiocarbamate, and Bz: benzoate); and their coordination behavior was characterized on the basis of elemental analyses, IR, electronic spectra, magnetic and conductivity measurements, and quantum chemical calculations. The magnetic moment measurement and electronic spectra were in agreement with the four proposed coordinate geometries for nickel and zinc complexes and were corroborated by the theoretical quantum chemical calculations. The quantum chemically derived thermodynamics parameters revealed that the formation of N-methyl-N-phenyl dithiocarbamate complexes is more thermodynamically favourable than that of the N-ethyl-N-phenyl dithiocarbamate complexes. The bioefficacy of the mixed-ligand complexes examined against different microbes showed moderate to high activity against the test microbes. The anti-inflammatory and antioxidant studies of the metal complexes showed that the ethyl substituted dithiocarbamate complexes exhibited better anti-inflammatory and antioxidant properties than the methyl substituted dithiocarbamate complexes.