Fucofuroeckol-A from Eisenia bicyclis Inhibits Inflammation in Lipopolysaccharide-Induced Mouse Macrophages via Downregulation of the MAPK/NF-κB Signaling Pathway

Figure 1

Elucidation of the structure of FF from the edible perennial brown alga Eisenia bicyclis (a). Effect of FF on LPS-induced NO production in RAW 264.7 macrophages (b). Effect of FF on LPS-induced production of PGE₂ in RAW 264.7 macrophages (c). Effect of FF on LPS-induced production of proinflammatory cytokines in RAW 264.7 macrophages (d). The cells were grown at a density of 1 × 10⁵ cells/well and treated with different concentrations of FF for 1 h before incubation with LPS (1 μg/mL) for 24 h. Each value was expressed as the mean ± SD of triplicate experiments. , , and as compared with LPS-treated cells (1 μg/mL). as compared with LPS nontreated cells.

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