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Journal of Chemistry
Volume 2016, Article ID 7678486, 8 pages
Research Article

Synthesis, Characterization, and Anticancer Activity of New Benzofuran Substituted Chalcones

1Department of Chemistry, Faculty of Science, Fırat University, 23119 Elazığ, Turkey
2Department of Physiology, Faculty of Medicine, Inonu University, 44000 Malatya, Turkey

Received 6 April 2016; Revised 26 April 2016; Accepted 8 May 2016

Academic Editor: Grigoris Zoidis

Copyright © 2016 Demet Coşkun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Benzofuran derivatives are of great interest in medicinal chemistry and have drawn considerable attention due to their diverse pharmacological profiles including anticancer activity. Similarly, chalcones, which are common substructures of numerous natural products belonging to the flavonoid class, feature strong anticancer properties. A novel series of chalcones, 3-aryl-1-(5-bromo-1-benzofuran-2-yl)-2-propanones propenones (3af), were designed, synthesized, and characterized. In vitro antitumor activities of the newly synthesized (3af) and previously synthesized (3gj) chalcone compounds were determined by using human breast (MCF-7) and prostate (PC-3) cancer cell lines. Antitumor properties of all compounds were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell viability assay for the tested chalcone compounds was performed and the values of the compounds were calculated after 24-hour treatment. Our results indicate that the tested chalcone compounds show antitumor activity against MCF-7 and PC-3 cell lines ().