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Journal of Chemistry
Volume 2016, Article ID 8510278, 13 pages
Review Article

Recent Advances in the Total Synthesis of Tetramic Acid-Containing Natural Products

1Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA
2College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, Jiangsu 225009, China

Received 2 March 2016; Accepted 29 March 2016

Academic Editor: Toyonobu Usuki

Copyright © 2016 Wen-Ju Bai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


With incredible bioactivities and fascinating structural complexities, tetramic acid- (TA-) containing natural products have attracted favorable attention among the organic chemistry community. Although the construction of the TA core is usually straightforward, the intricate C3-side chain sometimes asks for some deliberative strategy so as to fulfill an elegant total synthesis. This review mainly covers some exceptional synthetic examples for each type of natural product in recent years, showcasing the great achievements as well as unsettled obstacles in this area, in the hope of accelerating the synthetic and biological investigations for this unique type of natural product.