Research Article

Synthesis and In Vitro AMPK Activation of Cycloalkyl/Alkarylbiguanides with Robust In Vivo Antihyperglycemic Action

Figure 4

3D binding model of compounds 46 into the nucleotide binding site of AMPK (γ subunit). Compounds 4 (cyan), 5 (blue), and 6 (green) are shown as stick models, whereas aminoacids are depicted as lines. A yellow dashed lines represent polar or electrostatic interactions.