Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones

Table 1

Cytotoxic activity of target compounds.

Number	Compounds	IC50 (µM)
		HepG2	LU-1	MCF-7
(1)	4a	>100	>100	>100
(2)	4b	>100	>100	>100
(3)	4c	>100	>100	>100
(4)	4d	>100	66.83	>100
(5)	8a	20.93	13.58	9.40
(6)	8b	55.82	56.82	48.48
(7)	8c	89.72	79.83	86.40
(8)	8d	86.46	64.56	65.72
(9)	8e	>100	>100	>100
(10)	12a	55.68	54.70	63.33
(11)	12b	95.30	99.55	>100
(12)	12c	>100	>100	>100
(13)	12d	>100	>100	>100
(14)	12e	>100	>100	>100
(15)	Ellipticine	1.71	1.87	1.91
(16)	(−)-Gossypol	4.5	4.3	4.0

Note. The reference substance, ellipticine, exhibited cytotoxic activity against HepG2 (ATCC-HB 8065), LU-1 (ATCC-HTB-57), and MCF-7 (ATCC- HTB22) with IC₅₀ values of 1.71, 1.87, and 1.91 μM, respectively. The values shown for these compounds are the average of three determinations.