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Journal of Chemistry
Volume 2017 (2017), Article ID 3831507, 8 pages
Research Article

Investigation of Antimicrobial, Antioxidant, and DNA Binding Studies of Bioactive Cu(II), Zn(II), Co(II), and Ni(II) Complexes of Pyrimidine Derivative Schiff Base Ligand

1Chemistry Research Centre, Mohamed Sathak Engineering College, Kilakarai, Tamilnadu 623806, India
2Research and Development Centre, Bharathiar University, Coimbatore, Tamilnadu 641046, India
3Department of Nature Sciences, University of Pitesti, 110040 Pitesti, Romania

Correspondence should be addressed to Liviu Mitu and Jeyaraj Dhaveethu Raja

Received 23 July 2017; Revised 5 September 2017; Accepted 1 October 2017; Published 20 November 2017

Academic Editor: Henryk Kozlowski

Copyright © 2017 Shahul Hameed Sukkur Saleem et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A new pyrimidine based Schiff base ligand (HL) and its four complexes of type [MLOAc]·H2O (Cu(II), 1; Zn(II), 2; Co(II), 3; and Ni(II), 4) have been synthesized and characterized by elemental analysis, MS, 1H-NMR, FT-IR, UV-visible, and ESR techniques. The electronic and ESR spectral data suggested that complexes 14 possess square planar geometry. Antimicrobial activities of HL and complexes 14 were tested against four bacteria (Staphylococcus aureus, Staphylococcus pneumonia, Salmonella enterica typhi, and Haemophilus influenzae) and two fungal strains (Aspergillus flavus and Aspergillus niger). These results show that complexes 14 have good antimicrobial activity compared to HL. The DNA cleavage activity of HL and complexes 14 was monitored by the agarose gel electrophoresis method. The antioxidant property of the prepared compounds was assessed by using 2,2′-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method. DNA binding properties of HL and complexes 14 have been investigated by electronic absorption technique and viscometric measurements.