Novel Thiazole Derivatives of Medicinal Potential: Synthesis and Modeling

Figure 2

ESP maps (solid surface at left side and clipped surfaces at the right side showing atoms). The results should improve our knowledge about the binding sites, which are of importance in medical applications. Color code bars reflect electrostatic potential energy values in kJ/mol. The redder the area is, the higher the electron density is susceptible to nucleophilic attack and the bluer the area is, the lower the electron density is that could easily binds with an electrophile.