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Journal of Chemistry
Volume 2017, Article ID 4746158, 10 pages
Research Article

Synthesis of Ibuprofen Conjugated Molecular Transporter Capable of Enhanced Brain Penetration

1India Innovation Research Centre, 465 Patparganj Industrial Area, Delhi 110092, India
2Department of Life Science, Division of Molecular and Life Science and Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Republic of Korea
3Department of Chemical Engineering, Soonchunhyang University, Asan, Republic of Korea
4Department of Pathology, Soonchunhyang University, Asan, Republic of Korea
5Department of Pharmaceutical Engineering, Soonchunhyang University, Asan, Republic of Korea

Correspondence should be addressed to Jungkyun Im;

Received 23 August 2016; Revised 28 November 2016; Accepted 29 November 2016; Published 16 January 2017

Academic Editor: Josefina Pons

Copyright © 2017 Goutam Biswas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Based on the strong evidences between inflammation and neurodegeneration, nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, are considered as effective agents to reduce the risk of Alzheimer’s and Parkinson’s disease. However, the clinical use of NSAIDs in these diseases is limited by low brain distribution. In this study, we had synthesized ibuprofen conjugate which has good brain penetration. S-(+)-Ibuprofen was covalently attached to a molecular transporter having FITC and eight terminal guanidine groups. This conjugate showed good cellular uptake property in live cells. It was also injected into a mouse and the distribution of the compound was examined in each organ. The conjugate was well delivered to mouse brain indicating the conjugate is able to cross the blood-brain barrier. Our novel synthetic ibuprofen conjugate will hopefully deliver other NSAIDs into brain and is therefore applicable to the neurodegenerative diseases treatment or prevention.