Synthesis of Ibuprofen Conjugated Molecular Transporter Capable of Enhanced Brain Penetration

Scheme 2

(a) SiO₂ with hexane-1% TFA and hexane-1% Et₃N, 73%; (b) (2), EDC, DMAP, and DMF, rt, 48 h, 52%; (c) 10% Pd/C, (50 psi), and MeOH-CH₂Cl₂ (9 : 1), rt, 12 h, 88%; (d) FITC-I, Et₃N, THF, and EtOH, rt, 36 h, 60%; (e) in EtOAc, rt, 24 h, 58%.