Research Article
1-(2-Chlorobenzyloxy)-3-[1,2,3]triazol-1-yl-propan-2-ol Derivatives: Synthesis, Characterization, and DFT-Based Descriptors Analysis
Table 1
Effect of catalyst, reducing agent, base, and solvent.
| Entry | Copper salt | Reducing agent | Base | Solvent | % yield |
| 7 | CuSO4 | Glucose | NaOH | MeOH-H2O | 34 | 8 | CuSO4 | Sodium ascorbate | none | tBuOH-H2O | 28 | 9 | CuI | None | NaOH | MeOH-H2O | 40 | 10 | CuI | None | DIPEA | MeOH | 35 | 11 | CuI | None | DIPEA | CH2Cl2 | 85 |
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