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Journal of Chemistry
Volume 2017, Article ID 5373049, 7 pages
Research Article

Synthesis and Pharmacological Activities of Pyrano[2,3-d]pyrimidine and Pyrano[2,3-d]pyrimidine-5-one Derivatives as New Fused Heterocyclic Systems

Chemistry Department, Faculty of Science, Ain Shams University, Abbassia, Cairo 11566, Egypt

Correspondence should be addressed to Naglaa F. H. Mahmoud; moc.oohay@yzwaf.aalgan

Received 7 April 2017; Revised 28 May 2017; Accepted 8 June 2017; Published 17 July 2017

Academic Editor: Orazio Nicolotti

Copyright © 2017 Naglaa F. H. Mahmoud et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Various fused oxazine such as 4-(4-methoxyphenyl)-3,7-dimethyl-1,4-dihydro-5H-pyrazolo [4′,3′:5,6]pyrano[2,3-d][]oxazin-5-one 2 has been prepared and utilized as a starting material for novel pyrazolopyranopyrimidinones 3, 5, 6, and 7a–c and pyrazolopyranopyrimidines 4, 9, 10, and 11 which are expected to possess considerable chemical and pharmacological activities. The structures of the new compounds have been elucidated by spectroscopic data and elemental analysis. The antioxidant and anticancer activities of synthesized products have been evaluated.