An Efficient Synthesis of Milnacipran Hydrochloride via Reductive Amination of Aldehyde

Table 2

Reagent mole equivalent optimization table.

Entry	DMP	Solvent	Yield%
1	0.8	DCM	50
2	0.9	DCM	70
3	1.0	DCM	83
4	1.1	MDC	95

b: Dess-Martin periodinane reagent.