Preparation and Optimization of 10-Hydroxycamptothecin Nanocolloidal Particles Using Antisolvent Method Combined with High Pressure Homogenization

Table 1

Experimental design of preparation of HCPTNPs.

HP	Lecithin	Sodium taurocholate	ASS	Poloxamer 188	Gelatin	SDS
600 bar	0.5 mg	0.5 mg	0.5 mg	0.5 mg	0.5 mg	0.5 mg
	2.5 mg	2.5 mg	2.5 mg	2.5 mg	2.5 mg	2.5 mg
800 bar	0.5 mg	0.5 mg	0.5 mg	0.5 mg	0.5 mg	0.5 mg
	2.5 mg	2.5 mg	2.5 mg	2.5 mg	2.5 mg	2.5 mg
1000 bar	0.5 mg	0.5 mg	0.5 mg	0.5 mg	0.5 mg	0.5 mg
	2.5 mg	2.5 mg	2.5 mg	2.5 mg	2.5 mg	2.5 mg