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Journal of Chemistry
Volume 2017, Article ID 6436185, 6 pages
Research Article

A Novel Green Synthesis of Thalidomide and Analogs

1Department of Chemistry, Stockton University, 101 Vera King Farris Drive, Galloway, NJ 08205-9441, USA
2Department of Chemistry and Earth Sciences, Qatar University, P.O. Box 2713, Doha, Qatar

Correspondence should be addressed to Yousef M. Hijji; aq.ude.uq@ijjih.fesuoy

Received 13 November 2016; Accepted 18 January 2017; Published 20 February 2017

Academic Editor: José L. Arias Mediano

Copyright © 2017 Ellis Benjamin and Yousef M. Hijji. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Thalidomide and its derivatives are currently under investigation for their antiangiogenic, immunomodulative, and anticancer properties. Current methods used to synthesize these compounds involve multiple steps and extensive workup procedures. Described herein is an efficient microwave irradiation green synthesis method that allows preparation of thalidomide and its analogs in a one-pot multicomponent synthesis system. The multicomponent synthesis system developed involves an array of cyclic anhydrides, glutamic acid, and ammonium chloride in the presence of catalytic amounts of 4-N,N-dimethylaminopyridine (DMAP) to produce thalidomide and structurally related compounds within minutes in good isolated yields.