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Journal of Chemistry
Volume 2017, Article ID 8180913, 8 pages
Research Article

Synthesis and Growth Stimulant Properties of 2-Acetyl-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one Derivatives

1National Agrarian University of Armenia, 74 Teryan Str., 0009 Yerevan, Armenia
2Armenian-Russian (Slavonic) State University, 123 H. Emin Str., 0051 Yerevan, Armenia
3STC OPC Molecule Structure Research Center of NAS RA, 26 Azatutyan Av., 0014 Yerevan, Armenia

Correspondence should be addressed to Aleksandr P. Yengoyan; ur.liam@nayogneya

Received 12 October 2016; Revised 5 December 2016; Accepted 12 December 2016; Published 18 January 2017

Academic Editor: Xinyong Liu

Copyright © 2017 Vergush A. Pivazyan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A convenient, accessible, and high yield method for preparing of 6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (1) by treatment of acetoacetic acid ethyl ester with thiourea in sodium methylate was developed. The alkylation of the latter with 3-chloro-pentane-2,4-dione and further regioselective cyclization of intermediate compound (2) in high yield afforded 2-acetyl-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one (3). The halogenation and some transformations of synthesized thiazolo[3,2-a]pyrimidine (3) due to its ketone group were carried out to obtain the corresponding carboxamide, carbothioamide, sulfonohydrazide, and oxime and its alkylated derivatives (5). At preliminary biological studies the synthesized compounds have shown growth stimulant properties. The activity of four of them was higher than 70%, compared with heteroauxin.