Synthesis and Antitumor Activity of Novel Pyridoxine-Based Bioisosteric Analogs of trans-Stilbenes

Table 2

Cytotoxicity of compounds 4b and 4c against an extended panel of normal and tumor cells.

IC50, μM

HSF

HEK-293

MCF-7

PC-3

MDA-MB-231

A-498

SNB-19

M-14

OVCAR-4

NCI-H322M

HCT-15

HCT-116

4b

291.0 ± 23.0

22.8 ± 2.4

1.9 ± 0.9

308.0 ± 6.0

18.7 ± 2.3

290.5 ± 12.9

745.7 ± 26.0

340.8 ± 32.3

441.4 ± 0.5

368.1 ± 10.7

234.6 ± 53.9

79.1 ± 0.9

4c

66.5 ± 3.0

>292.9

7.9 ± 4.9

48.6 ± 3.3

43.7 ± 5.1

86.5 ± 2.2

82.4 ± 0.5

89.6 ± 8.5

66.9 ± 1.5

48.1 ± 4.8

80.7 ± 8.0

Doxorubicin

2.2 ± 0.2

1.2 ± 0.1

1.2 ± 0.1

14.1 ± 1.0

0.12 ± 0.01

12.2 ± 0.9

6.1 ± 0.5

3.4 ± 0.2

67.3 ± 3.0

124.0 ± 14.0

2.2 ± 0.3

0.38 ± 0.12

: not measured.