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Journal of Chemistry
Volume 2017, Article ID 9343824, 8 pages
https://doi.org/10.1155/2017/9343824
Research Article

A Transdermal Measurement Platform Based on Microfluidics

1Department of Applied Cosmetology and Master Program of Cosmetic Science, Hungkuang University, Taichung 43302, Taiwan
2Department of Chemical Engineering, National United University, Miaoli 36063, Taiwan

Correspondence should be addressed to Yung-Sheng Lin; wt.ude.uun@synil

Received 21 September 2017; Accepted 3 December 2017; Published 25 December 2017

Academic Editor: Lorena Tavano

Copyright © 2017 Wen-Ying Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The Franz diffusion cell is one of the most widely used devices to evaluate transdermal drug delivery. However, this static and nonflowing system has some limitations, such as a relatively large solution volume and skin area and the development of gas bubbles during sampling. To overcome these disadvantages, this study provides a proof of concept for miniaturizing models of transdermal delivery by using a microfluidic chip combined with a diffusion cell. The proposed diffusion microchip system requires only 80 μL of sample solution and provides flow circulation. Two model compounds, Coomassie Brilliant Blue G-250 and potassium ferricyanide, were successfully tested for transdermal delivery experiments. The diffusion rate is high for a high sample concentration or a large membrane pore size. The developed diffusion microchip system, which is feasible, can be applied for transdermal measurement in the future.