Synthesis and Biological Evaluation of 1,3,8-Triazaspiro[4.5]decane-2,4-dione Derivatives as Myelostimulators

Figure 2

Myelogram of myeloid cells (a), the lymphoid cells (b), the granulocyte cells (c), and the erythrocyte cells (d) in the mice bone marrow, administration of 11 after the injection of cyclophosphamide solution (1), administration of 6 after the injection of cyclophosphamide solution (2), administration of 9 after the injection of cyclophosphamide solution (3), administration of methyluracil after the injection of cyclophosphamide solution (4), control group (administration of placebo (saline) after the injection of cyclophosphamide solution) (5), and intact animals (6). Time in days, in parentheses, days after administration of the compounds (the abscissa axis); number of cells ⋅ 10⁶/μL (the axes of ordinates).

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