Research Article

Thiadiazoline- and Pyrazoline-Based Carboxamides and Carbothioamides: Synthesis and Inhibition against Nitric Oxide Synthase

Figure 4

Effects of 6m on eNOS activity. (a) Acetylcholine- (Ach-) evoked relaxation in aortic rings with endothelium contracted with 1 μmol/L phenylephrine under basal conditions and after incubation with DMSO, 6m (0.1, 0.5, 1 mmol/L), or L-NAME (1 mmol/L) for 30 min (). (b) Area under relaxant-response curve (AUC) to Ach from experiments to (a). Data are expressed as the mean ± SEM of experiments. versus vehicle group.